Focusing primarily on physics and engineering, our laboratory develops artificial organs such as artificial hearts, artificial lungs, artificial kidneys, and artificial pancreases. Our goal is to realize intelligent artificial organs in which mechanically created organs can “think autonomously” and function in accordance with the physiological condition of the body. Autonomy here refers to the cycle of recognition, reasoning, and action. In other words, artificial organs require “nerves” in the form of sensors to perceive biological conditions. We utilize noninvasive optical sensing technologies as these sensors. Such noninvasive optical measurement techniques can also be applied to healthcare. By integrating measurement, control, and information systems, our laboratory aims to create unprecedented healthcare and medical devices.